Unwanted pharmacological effects of local guanethidine in the treatment of dysthyroid upper lid retraction.
نویسندگان
چکیده
Adrenergic blocking agents have had an occasional and limited use in ophthalmology for several years but are now being used with increasing frequency in the treatment of glaucoma and of the eye signs of accompanying thyroid dysfunction. Several trials of the therapeutic uses of local adrenergic blocking agents have been made and these indicate that, of the agents tested (including Bethanidine, Guanethidine, Phentolamine, and Propanolol), Guanethidine is the most effective (Lee, Morimoto, Bronsky, and Waldstein, I 96 I; Gay and Wolkstein, I 966; Sneddon and Turner, I 966; Gay, Salmon, and Wolkstein, 1967). Accordingly, with increasing interest in dysthyroid ophthalmopathy, trials have recently been made of the use of Guanethidine in treating upper lid retraction and exophthalmos and, as local toxic effects have been met in some of these trials, including a short-term trial with fourteen patients (Sneddon and Turner, I966) and a long-term trial with twenty patients and an average duration of i6 weeks (Crombie and Lawson, I967), 81 patients in a recent extended trial have been examined in detail to determine if local Guanethidine has any serious side-effects.
منابع مشابه
Dysthyroid eye disease. A trial of guanethidine eye drops.
Previous reports have indicated the usefulness of Io per cent. Guanethidine eye-drops in reducing lid retraction and relieving symptoms in patients with dysthyroid eye disease (Sneddon and Turner, I966; Gay and Wolksteip, I966; Crombie and Lawson, I967). Administration of these eye drops produces local irritation in about 50 per cent. of patients and, although this is rarely severe, superficial...
متن کامل[Evaluation of extraocular muscle enlargement in dysthyroid ophthalmopathy].
PURPOSE To evaluate the extraocular muscle enlargement in dysthyroid opthalmopathy. METHOD Extraocular muscle enlargement was assessed by orbital computed tomography (CT) in 573 patients with dysthyroid ophthalmopathy in order to investigate the frequency and exact location of extraocular muscle enlargement and the clinical features of related ocular symptoms in patients with dysthyroid ophth...
متن کاملAdrenergic blocking agents. A double-blind trial in the treatment of the eye signs of thyroid disorders.
LID retraction and lid lag in thyrotoxicosis have been diminished by intramuscular reserpine (Canary, 1957), oral guanethidine (Waldstein, West, Lee, and Bronsky, 1964), and oral propranolol (Buckfield and Davis, 1966), while the increasing availability of local ophthalmic preparations of adrenergic blocking agents has resulted in the local use of propranolol (Sneddon and Turner, 1966), phentol...
متن کامل[Morphometric analysis of eyelid fissure in patients with eyelid retraction in acute stage of dysthyroid orbitopathy after treatment with botulinum toxin type A].
PURPOSE To compare morphometric data of eyelid fissure using computerized image analysis before and after application of botulinum toxin type A in patients with eyelid retraction caused by dysthyroid orbitopathy in acute stage. METHODS This was a prospective study with 12 individuals that received transcutaneous 5 UI/0.1 ml injection of botulinum toxin in the upper eyelid. They were examined ...
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ورودعنوان ژورنال:
- The British journal of ophthalmology
دوره 53 4 شماره
صفحات -
تاریخ انتشار 1969